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产品目录

TOP2A-Specific抗体图片
产品货号:
Z28259
中文名称:
TOP2A-Specific抗体
英文名称:
Anti-TOP2A-Specific Antibody
产品规格:
50μl|100μl|150μl
发货周期:
1~3天
产品价格:
询价
抗体名称Anti-TOP2A-Specific Antibody
指标别名DNA topoisomerase 2 alpha;TOP2;TOP2A;TOP2A-Specific;TP2A
克隆性Polyclonal
检验物种human
应用范围WB
基因名称TOP2A
抗体来源Rabbit
抗体类型IgG
免疫原A synthetic peptide corresponding to a sequence at the C-terminus of human Topoisomerase II alpha(1466-1480aa RKPSTSDDSDSNFEK),different from the related rat sequence by three amino acids,and different from the related mouse sequence by four amino acids.
实际分子量174KD
成分500μg/mL antibody with PBS,0.02% NaN3,1mg BSA and 50% glycerol.
纯化方式Immunogen affinity purified.
浓度500μg/mL
产品形态溶液
保存条件12 months from date of receipt,-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing.
背景资料The human topoisomerase II enzyme is encoded by a single-copy gene which is mapped to 17q21-q22.The TOP2A gene spans approximately 30kb and contains 35 exons.Furthermore,DNA topoisomerases are enzymes that control and alter the topologic states of DNA in both prokaryotes and eukaryotes.Topoisomerase II from eukaryotic cells catalyzes the relaxation of supercoiled DNA molecules,catenation,decatenation,knotting,and unknotting of circular DNA.It appears likely that the reaction catalyzed by topoisomerase II involves the crossing-over of 2 DNA segments.There are about 100,000 molecules of topoisomerase II per HeLa cell nucleus,constituting about 0.1% of the nuclear extract.DNA topoisomerase II-alpha is associated with the pol II holoenzyme and is a required component of chromatin-dependent coactivation.Specific inhibitors of topoisomerase II blocked transcription on chromatin templates,but did not affect transcription on naked templates.Addition of purified topoisomerase II-alpha reconstituted chromatin-dependent activation activity in reactions with core pol II.
Uniprot IDP11388
推荐配套试剂Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。
基因名全称topoisomerase(DNA) II alpha 170kDa
蛋白名全称DNA topoisomerase 2-alpha
推荐稀释比
Western blot(WB) 1:500~2000

相关搜索:TOP2A-Specific抗体TOP2A-Specific多抗Anti-TOP2A-Specific Antibody
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